What is CAR T-cell therapy?

CAR T-cell therapy is a type of adoptive cell therapy, custom made for each patient using their own T-cells. Our T-cells play a vital role in our immune system, orchestrating the immune response in our bodies by killing cells that have become infected by pathogens (bacteria or germs capable of causing disease).  

On the surface of every cancer cell, there are specific antigens relating to that type of cancer. These are foreign toxins that normally induce an immune response within our body. However, sometimes our T-cell lymphocytes that search for infections stop recognising antigens as foreign and no longer destroy them, which is how cancer develops.  In CAR T-cell therapy, these genetically modified T-cells are designed to recognise and eradicate specific antigens on tumour cells.  

CAR T-cell therapy is the latest breakthrough in immunotherapy treatment and can be used to treat some blood cancers that have not responded to conventional chemotherapy.


At HCA Healthcare UK, we are committed to providing the very best care and access to emerging therapies as soon as they are available. We will be one of the first JACIE accredited private providers in the UK to offer the latest CAR T-cell therapy.

To see how CAR T-cell therapy works, watch our video.

CAR T-cell therapy, a novel type of immunotherapy, is designed to strengthen and harness the immune system's inherent cancer-eliminating powers and remove its disguise.

What is CAR T-cell therapy?

CAR T-cell therapy involves the adoptive transfer of T-cells that have been genetically modified with a chimeric antigen receptor (CAR) to target a tumour. CAR T-cells are intended to provide immediate and specific activity against tumour cells that contain the antigen to which the CAR is aimed.

Early data outcomes from this exciting new treatment have so far shown very promising results for many patients.

Whilst CAR T-cell therapy is an exciting step change in blood cancer treatment, at this stage it's not suitable for all patients. Our leading MDTs will ensure every individual patient's case is reviewed, in order to ensure patients that can benefit from this treatment can access it at a specialist centre.

Who is CAR T-cell therapy suitable for?

CAR T-cell therapy is used to treat patients who have not responded to standard first and second line treatment. Initially we will be accepting referrals for patients over 18 with: diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, transformed follicular lymphoma and mantle cell lymphoma. We are preparing to accept referrals for other types of blood cancers soon.

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    Acute lymphoblastic leukaemia

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    Transformed follicular lymphoma

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    Primary mediastinal large b-cell lymphoma

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    Diffuse large B-cell lymphoma

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    Mantle cell lymphoma

Our CAR T-cell therapy consultants

Consultant

Dr Kirit Ardeshna thumbnail

Dr Kirit Ardeshna

Consultant Haematologist

Specialties

Private Haematologists in London: Lymphoma

Works at

HCA UK at University College Hospital

Consultant

Dr Panagiotis Kottaridis thumbnail

Dr Panagiotis Kottaridis

Consultant Haematologist

Specialties

Private Haematologists in London: Leukaemia,Blood cancers

Works at

HCA UK at University College Hospital

Consultant

Christopher Mcnamara thumbnail

Dr Christopher McNamara

Consultant Haematologist

Specialties

Private Haematologists in London: Lymphoma

Works at

HCA UK at University College Hospital

LOC - Leaders in Oncology Care

Devonshire Diagnostic Centre

The Princess Grace Hospital

London Digestive Centre

The Harley Street Clinic

London Bridge Hospital

The Wellington Hospital

LOC at 95 Harley Street

LOC at Platinum Medical Centre

LOC in HCA UK at University College Hospital

A collaborative approach to patient care

We work with some of the UK’s leading haematology consultants and are in a unique position to bring together multidisciplinary teams (MDTs) from renowned teaching hospitals including: University College London Hospital, Imperial College, Guy’s and St Thomas’ Hospital, King’s college Hospital, The Royal Marsden, St George’s, St Bartholomews’s and The Christie.

These MDTs of leading specialists come together to discuss treatment options and ensure the best treatment pathway is always delivered to each patient.  
JACIE logo

A comprehensive haematology service

At HCA Healthcare UK we have developed comprehensive haematology services including dedicated JACIE-ISCT accredited haematopoietic stem cell transplant units.  We work in partnership with some of the UK’s most prestigious university teaching hospitals and are one of the only private providers in the UK to offer these complex haematology services.

All of our hospitals that provide these complex haematology services have achieved the highest rating of ‘Outstanding’ from the CQC.
 

Our CAR T-cell centre

Harley Street Clinic at UCH Facility

HCA UK at University College Hospital

Contact us about CAR T-cell therapy

Please get in touch if you would like to know more information about CAR T-cell therapy, including the treatment process, suitability to receive therapy, referral from your consultant for therapy and the cost of treatment. 

This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.
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