Seronegative arthritis

Seronegative inflammatory arthritis

If a specific protein is found in your blood you may be diagnosed with this type of arthritis

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About

Arthritis can be divided into two types: seropositive and seronegative. These refer to the presence of two proteins in your blood. Your type is determined by a blood test. One protein is called rheumatoid factor (RF) and the other is anti-CCP. Anti-CCP is more sensitive and may appear earlier. Seronegative arthritis affects a minority of cases.

Need to know

  • Symptoms of seronegative arthritis icon plus

    Symptoms may include:

    • painful and swollen joints
    • stiffness
    • tiredness

  • Diagnosis icon plus

    Your consultant will speak to you about your symptoms, discuss your medical history and perform a physical examination of your affected joints. To confirm a diagnosis they may ask you to carry out some, or all, of the following tests:

    • a blood test to check for two proteins (RF and anti-CCP)
    • X-ray, CT or MRI scans of the affected joints

  • Potential treatment options icon plus

    Treatment options include:

    • over-the-counter painkillers and non-steroidal anti-inflammatory drugs (NSAIDs)
    • disease-modifying anti-rheumatic drugs (DMARDs)
    • steroids
    • biologics (used for severe cases)

    In severe cases, surgery may be recommended. Possible procedures include hip, knee and ankle replacements.

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This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.
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