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Seronegative arthritis
SERONEGATIVE INFLAMMATORY ARTHRITIS
If a specific protein is found in your blood you may be diagnosed with this type of arthritis
About
Arthritis can be divided into two types: seropositive and seronegative. These refer to the presence of two proteins in your blood. Your type is determined by a blood test. One protein is called rheumatoid factor (RF) and the other is anti-CCP. Anti-CCP is more sensitive and may appear earlier. Seronegative arthritis affects a minority of cases.
Need to know
Symptoms may include:
- painful and swollen joints
- stiffness
- tiredness
Your consultant will speak to you about your symptoms, discuss your medical history and perform a physical examination of your affected joints. To confirm a diagnosis they may ask you to carry out some, or all, of the following tests:
- a blood test to check for two proteins (RF and anti-CCP)
- X-ray, CT or MRI scans of the affected joints
Treatment options include:
- over-the-counter painkillers and non-steroidal anti-inflammatory drugs (NSAIDs)
- disease-modifying anti-rheumatic drugs (DMARDs)
- steroids
- biologics (used for severe cases)
In severe cases, surgery may be recommended. Possible procedures include hip, knee and ankle replacements.
Our Seronegative arthritis locations
The Harley Street Clinic
35 Weymouth Street W1G 8BJ London
The Princess Grace Hospital
42-52 Nottingham Place W1U 5NY London
The Lister Hospital
Chelsea Bridge Road, SW1W 8RH London
The Shard Outpatients
The Shard, 32 St Thomas Street SE1 9BS London
London Lupus and Rheumatology Centre
1st Floor, St. Olaf House SE1 2PR London
London Bridge Hospital
27 Tooley Street SE1 2PR London
Patient stories
Yvette's story: From back pain to hip replacement surgery
Yvette (54) a journalist from Kent, started experiencing pain in her hip seven years ago in 2015. An ex-national gymnast who had been incredibly active and flexible her whole life, Yvette felt concerned about the growing discomfort impacting her quality of life, and so sought help from her GP.
A new hip and straight back into the spin of things
David's gym video shows him repeatedly pushing up to 100kg on a single leg press – not particularly unusual for this keen cyclist former competitive squash player and all-round fitness enthusiast. What is unusual is that 52-year-old David had hip surgery just 12 weeks earlier.
Michael's MAKO hip surgery to treat his arthritis
73 year-old Michael, an avid walker and charity worker, was diagnosed with arthritis in January 2021. After facing long waiting times and increasing pain that was becoming more frequent, he started to look elsewhere for treatment.
This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.