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Seronegative arthritis
SERONEGATIVE INFLAMMATORY ARTHRITIS
If a specific protein is found in your blood you may be diagnosed with this type of arthritis
About
Arthritis can be divided into two types: seropositive and seronegative. These refer to the presence of two proteins in your blood. Your type is determined by a blood test. One protein is called rheumatoid factor (RF) and the other is anti-CCP. Anti-CCP is more sensitive and may appear earlier. Seronegative arthritis affects a minority of cases.
Need to know
Symptoms may include:
- painful and swollen joints
- stiffness
- tiredness
Your consultant will speak to you about your symptoms, discuss your medical history and perform a physical examination of your affected joints. To confirm a diagnosis they may ask you to carry out some, or all, of the following tests:
- a blood test to check for two proteins (RF and anti-CCP)
- X-ray, CT or MRI scans of the affected joints
Treatment options include:
- over-the-counter painkillers and non-steroidal anti-inflammatory drugs (NSAIDs)
- disease-modifying anti-rheumatic drugs (DMARDs)
- steroids
- biologics (used for severe cases)
In severe cases, surgery may be recommended. Possible procedures include hip, knee and ankle replacements.
Our Seronegative arthritis locations
The Harborne Hospital
Mindelsohn Way B15 2TQ Birmingham
Patient stories
Hear from past patients about their experience
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Richard's story
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Sarah's story
Sarah, a health copywriter, aged 47, from Birmingham, was looking forward to enjoying the first few months of married life, when her painful periods revealed a diagnosis of endometriosis and metastatic appendix cancer.