Cirrhosis

Liver disease

Cirrhosis results from long-term, continuous damage to the liver and may have many causes.

What is cirrhosis of the liver?

Cirrhosis is the result of long-term, continuous damage to the liver and may have many different causes. The damage leads to scarring known as fibrosis.

Irregular bumps (nodules) replace the smooth liver tissue and the liver becomes harder. Together, the scarring and nodules are called cirrhosis.

Cirrhosis can lead to liver failure or liver cancer.

Need to know

  • What are the symptoms of cirrhosis? icon plus

    Early symptoms include:

    • tiredness and weakness
    • loss of appetite
    • loss of weight and muscle wasting
    • nausea and vomiting
    • tenderness or pain in the liver area
    • spider-like small blood capillaries on the skin above waist level (spider angiomas)
    • disturbed sleep pattern

    Later symptoms as the liver struggles to function include:

    • swelling of the legs, ankles and feet (oedema) or abdomen (ascites)
    • extreme fatigue (anaemia)
    • irregular periods (amenorrhoea)
    • rapid heartbeat (tachycardia)
    • vomiting blood
    • jaundice
    • dark urine
  • How is cirrhosis diagnosed? icon plus

    Your consultant will discuss your symptoms with you and may recommend tests to aid diagnosis. Diagnosis is made through a combination of an assessment of your medical history, a physical examination and certain diagnostic tests. These might include:

    • Blood tests, commonly liver function tests (LFTs) that measure, for example, levels of liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) which are elevated during inflammation.
    • Imaging tests such as a CT or MRI scan.
    • Fibroscan to assess liver fibrosis.
    • A liver biopsy may be required, where a tiny piece of your liver is taken to determine the cause of cirrhosis.
    • An endoscopy to check for varices (abnormally dilated vessels) in the oesophagus or stomach which may rupture and bleed.
  • Potential treatment options icon plus

    Treatment will depend on the cause and stage of cirrhosis. The aims of treatment are usually to stop the cirrhosis from getting worse, to reverse any damage (if this is possible) and to treat any disabling or life-threatening complications. Treatment options may include:

    • Making lifestyle changes such as sodium restriction and giving up alcohol.
    • Antiviral medications or corticosteroids.
    • Beta blockers which can reduce the risk of bleeding and the severity of any bleed, should it occur.

    A liver transplant is usually only recommended if other treatments are no longer helpful and your life is threatened by end stage liver disease.

     

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We have a teams of liver specialists across our HCA UK network, which include hepatologists, liver surgeons and clinical nurse specialists. 

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From complex liver surgery to test and diagnostic procedures, we provide exceptional HPB care across our network of hospitals, outpatient centres and specialist clinics.

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This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.
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