Hughes syndrome

Antiphospholipid syndrome

An immune system disorder that causes an increased tendency for blood clots to form in your veins or arteries

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About

Hughes syndrome or antiphospholipid syndrome is an immune system disorder that can lead to an increased risk of developing the following:
  • blood clots in the leg
  • a clot in an artery which can cause a stroke or heart attack
  • blood clots in the brain, leading to problems with balance, mobility, vision, speech and memory
  • an increased risk of miscarriage in pregnant women

Need to know

  • Symptoms of Hughes syndrome icon plus

    Without treatment, Hughes syndrome can cause many symptoms and complications, including:

    • migraine headaches
    • mottled skin tone (livedo reticularis)
    • low blood platelet count (thrombocytopenia)
    • vein thrombosis
    • deep vein thrombosis (DVT)
    • arterial thrombosis
    • heart attack
    • stroke
    • catastrophic antiphospholipid syndrome

  • Diagnosis icon plus

    Tests carried out by our consultants to diagnose Hughes syndrome include:

    • taking a medical history
    • a physical examination
    • blood tests.

    If Hughes syndrome is suspected, you'll usually be referred to an HCA UK facility to see either a rheumatologist (specialist in conditions affecting the immune system) or a haematologist (specialist in conditions affecting the blood).

  • Potential treatment options icon plus

    The goal of treatment for Hughes syndrome is to reduce your risk of developing blood clots.  We offer a number of treatment options.

    • Medication. Such as anticoagulant medicine or an antiplatelet medication
    • Recommended lifestyle changes such as healthy eating, regular exercise, losing weight and not smoking.

    Women diagnosed with the condition are strongly advised to plan before they become pregnant. This is because treatment is most effective when it begins immediately after conception. Some medications used to treat Hughes syndrome may also be harmful to an unborn baby. More information on Hughes Syndrome is available on the Graham Hughes International Charity website

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This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.
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