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Health: Fact vs Fiction - Genes unzipped

Genes unzipped

What makes you ‘you’? How much of your future health is shaped by your ancestors and, is there a way to predict or prevent it? 

 

Anna Richardson is joined by Dr Anju Kulkarni from HCA UK’s London Bridge Hospital, to unzip the secrets of our genes and dive into the past, present and future of our health.  

 

They are joined by popstar and presenter Michelle Heaton who talks movingly about how inheriting the BRCA gene, a gene that increases a woman’s risk of getting breast and ovarian cancer, has changed her life.

 

Listen to Health: Fact vs Fiction - Genes unzipped on Apple podcasts now.

Listen to Health: Fact vs Fiction - Genes unzipped on Google podcasts now.

Listen now

Anju Kulkarni

Dr Anju Kulkarni

Dr Anju Kulkarni, Consultant Clinical Geneticist at The London Bridge Hospital, part of HCA Healthcare UK.

 

Dr Anju Kulkarni leads the South East Thames Cancer Genetics Service, which serves a population of approximately five million across South London, Kent and East Sussex.

 

Anju graduated with distinctions in Medicine and Pathology from Imperial College School of Medicine and subsequently trained at specialist level in Medical Oncology, at University College London Hospital, and Clinical Genetics at Guy’s and St Thomas’ hospital, the Kennedy-Galton centre and the Royal Marsden hospital, before being appointed to her current NHS consultant post.

 

She has developed several regional guidelines for the management of individuals with an inherited susceptibility to cancer. She leads multidisciplinary specialist clinics for BRCA1/2 gene mutation carriers and other rarer hereditary cancer conditions and is medical advisor to the Genetic Counselling Registration Board. She has extensive clinical and academic experience in cancer genetics and has published, presented and taught on the topic at a national and international level.

Michelle Heaton

Michelle Heaton

Michelle Heaton is best known for being a singer in the band Liberty X. She is also an actress, TV presenter and well-known fitness enthusiast.  

 

Her two children, Faith and AJ, also keep her and her husband Hugh Hanley very busy, with Michelle being a formed winner of Disney's Mum of the Year. 

 

More recently Michelle has hit the headlines for making the brave decision to have preventative surgery (a double mastectomy and hysterectomy) to prevent cancer, due to the strong genetic predisposition in her family (the BRCA gene).  With this plunging her into early surgical menopause, this year Michelle released the book Hot Flush, Motherhood, the Menopause and Me.

Our location

  • London Bridge Hospital Facility

    London Bridge Hospital

    27 Tooley Street

    London

    SE1 2PR

    Appointments and Enquiries 020 7234 2009
    Imaging Appointments 020 7234 2773
    Switchboard 020 7407 3100

Things we learn in this episode

Fact

We've got 20,000 genes in our bodies. And we don't know what most of them do yet.

Anju describes genes as our instructions for how we grow and develop. It’s like our own recipe book. Mutated genes are effectively like spelling mistakes or missing words in that recipe book.

Fiction

If you look like your mum, you're going to inherit her health problems.

Anju says that while you might have your mum’s blue eyes, that doesn’t mean you’re going to get her ailments. In this episode, Anju guides us through how genes are passed from generation to generation.

Fiction

Most of the cancers that people get are inherited.

In fact, most cancerous cell mutations are down to environmental factors. Only about 3-5% of all cancers are due to an inherited gene mutation.

Fact

You’re as likely to get the mutated ovarian cancer gene from your dad as you are from your mum.

It’s a misconception that mutated genes, like BRCA, are only passed down the maternal line. Dads can be carriers of mutated breast and ovarian cancer genes too. That’s what happened to Michelle Heaton. The TV presenter and chart-topping pop star found out she was carrying the mutated dominant gene, BRCA2 in 2012. Having the mutated BRCA2 gene significantly increases someone’s chances of getting breast or ovarian cancer. Michelle tells us about her decision to undergo a double mastectomy and total hysterectomy to reduce the risk of contracting the disease - and her fears that she may have passed the mutated gene on to her young daughter. 

 

Anju talks about the counselling support available to women to help reach the right decision for them if they are carrying a mutated gene like BRCA. And she says it’s important that women and men who feel they are at risk of cancer see their GP or get expert advice from consultant clinical geneticists or genetic counsellors, rather than seek out tests online.

What to do next

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